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Although most ribozymes are quite rare in the cell, their roles are sometimes essential to life.
im going to check on this with our Bio teacher in the morning. It just doesnt make much sense to me.mindinflight wrote: I'm taking Wikipedia's word for it here, added onto some jumbled AP Biology facts I remember from this year. *shrugs* I could be wrong, but hey, it's all speculation, right?
You just have to remember that Wiki can be edited by anyone. So you may not get the right stuff all the time.mindinflight wrote:Gah, I'm so full of crap. Damn Wikipedia....
Also, someone might have gotten there just before you did, knowing we would be researching it now.LittleChickie wrote:You just have to remember that Wiki can be edited by anyone. So you may not get the right stuff all the time.mindinflight wrote:Gah, I'm so full of crap. Damn Wikipedia....
First Jepordy(sp?) and now Wikipedia!!!! When will the madness end!!?? lolSARAHPHOBIA88 wrote:Also, someone might have gotten there just before you did, knowing we would be researching it now.LittleChickie wrote:You just have to remember that Wiki can be edited by anyone. So you may not get the right stuff all the time.mindinflight wrote:Gah, I'm so full of crap. Damn Wikipedia....
Ha ha ha ha ha ha hah ha!LittleChickie wrote:First Jepordy(sp?) and now Wikipedia!!!! When will the madness end!!?? lolSARAHPHOBIA88 wrote:Also, someone might have gotten there just before you did, knowing we would be researching it now.LittleChickie wrote: You just have to remember that Wiki can be edited by anyone. So you may not get the right stuff all the time.
mindinflight wrote: Turns out they aren't that rare, just available in teeny tiny, hard-to-harvest doses -- the functional part of a ribosome, the bit that synthesizes the protein? Yeah. Essentially a ribozyme. I looked it up. And that's just one example...
thats what confused me. without ribozymes, you would have a hard time making proteins..
no problem at all.mindinflight wrote: That's what you get for jumping to conclusions I suppose... sorry staticmorning.
the world may never know...The chicken or the auto-catalytic RNA?
Haether, ok, but do you think this sort of information: Ribozyme Cleavage Leads to Decreased Expression of Fibroblast Growth Factor Receptor 3 in Human Multiple Myeloma Cells, Which Is Associated with Apoptosis and Downregulation of Vascular Endothelial Growth Factor will really help the plot discussion? Just asking.Haether wrote:
some interesting articles (you may need to be on a university system to access these, I'm connected to Johns Hopkins on a VPN...if you're really curious, PM me):
oh come on, I cannot be the only person who has some background in molecular biology on here.impulse wrote:Haether, ok, but do you think this sort of information: Ribozyme Cleavage Leads to Decreased Expression of Fibroblast Growth Factor Receptor 3 in Human Multiple Myeloma Cells, Which Is Associated with Apoptosis and Downregulation of Vascular Endothelial Growth Factor will really help the plot discussion? Just asking.Haether wrote:
some interesting articles (you may need to be on a university system to access these, I'm connected to Johns Hopkins on a VPN...if you're really curious, PM me):
The idea of a catalytic role for snRNA arose from the discovery of ribozymes. RNA molecules that function as enzymes. In some organisms, RNA splicing can occur without proteins or additional RNA molecules: The intron RNA functions as a ribozyme and catalyzes its own excision! For example, in the protozoan Tetrahymena, self-splicing occues in the production of ribosomal RNA (rRNA), a component of the organism's ribosomes. The pre-rRna actually removes it's own introns.
The fact that RNA is single stranded plays an important role in allowing certain RNA molecules to function as ribozymes. A region of an RNA molecules may base-pair with a complementary region elsewhere in the same molecules, this imparting specific structure to the RNA molecules as a whole. Also, some of the bases contain functional groups that may participate in catalysis. Just as the specific shape of an enzymatic protein and the functional groups on its amino acid side chains allow the protein to function as a catalyst, the structure of some RNA molecules allows them to function as catalysts too. The discovery of ribozymes rendered obsolete the belief that all biological catalysts were proteins.
Thomas Cech, of the University of Colorade and Sidney Altman of Yale University found that RYNA, which plays a central role in protein synthesis, can also carry out a number of enzyme-like catalytic functions. Cech called these RNA catalysts Ribozymes. Some ribosymes can make complementary copies of short pieces of RNA, provided that they are supplied with nucleotide building blocks.
