Lonelygirl15

Yea so i'm uber bored this morning, so i went on some researching binge.

What I have discovered is this:

tricarboxylate carrier, better known as TCC ...
Quote:
is an integral protein of the mitochondrial inner membrane.


WHAT???

Alright, so what that means is that it is one of the many building blocks involved in the structure of a mitochondrion.

Mitochondria (plural...) is esentially a cell's power plant. It generates the chemicaal energy needed by the cell to function.

Quote:
The inner mitochondrial membrane contains proteins with four types of functions: [2]

1. Those that carry out the oxidation reactions of the respiratory chain.
2. ATP synthase, which makes ATP in the matrix.
3. Specific transport proteins that regulate the passage of metabolites into and out of the matrix.
4. Protein import machinery.


WHAT!!!????!!!!

It's imports and exports things.

alright...so that is veering off topic. but I thought a nice bio lesson would be nice.

Ooook ... Next I will talk about the Thyroid.

Quote:
The thyroid is one of the largest endocrine glands in the body. This gland is found in the neck just below the Adam's apple. The thyroid controls how quickly the body burns energy, makes proteins, and how sensitive the body should be to other hormones.


I would like to move on to two issues thyroids often have. Hyperthyroidism, and Hypothyroidism.

Hyper:

in the basic terms without a bunch of balo-hy:

Quote:
Hyperthyroidism is the result of excess thyroid hormone production, causing an overactive metabolism and increased speed of all the body's processes.


Hypo:
Quote:
Hypothyroidism is the disease state in humans and animals caused by insufficient production of thyroid hormone by the thyroid gland


TCC Connection:

Quote:
The tricarboxylate carrier (TCC), also known as citrate carrier, is an integral protein of the mitochondrial inner membrane. It is an essential component of the shuttle system by which mitochondrial acetyl-CoA, primer for both fatty acid and cholesterol synthesis, is transported into the cytosol, where lipogenesis occurs. The effect of hypothyroidism on the activity and expression of the hepatic mitochondrial TCC was investigated in this study. TCC activity was significantly decreased in hypothyroid rats as compared with euthyroid animals. This hormone deficiency effect was due to a reduction in the amount of carrier protein, which resulted from a proportionate decrease of the specific mRNA. Hypothyroidism did not influence TCC mRNA stability. On the other hand, nuclear run-on assay revealed that the transcriptional rate of TCC mRNA decreased by ~40% in the nuclei from hypothyroid versus euthyroid rats. In addition, the ribonuclease protection assay showed that, in the nuclei of hypothyroid rats, the ratio of mature to precursor RNA decreased, indicating that the splicing of TCC RNA is affected. Furthermore, we found that the ratio of polyadenylated/unpolyadenylated TCC RNA as well as the length of the TCC RNA poly(A) tail were similar in both euthyroid and hypothyroid rats. Thus, the rate of formation of the TCC 3'-end is not altered in hypothyroidism. These results suggest that hypothyroidism affects TCC expression at both the transcriptional and post-transcriptional levels.


Correct me if I'm wrong, but I believe this, in basic every day terms means that the TCC could not carry the energy from the mitochondrion to the cell nuclious (i think if i remember things right) like it is supposed to if the case is Hypothyroidism.


(spenc...i'm really wondering if i'm right with this one...)




Soooo where does Epogen come into this...

(spenc : we know that the order wanted Bree to take Epogen on a regular basis. Almost once a week.)
( i just almost lost this all...ugh stupid computer...)

Quote:
Rheumatoid-collagen disease, chronic liver disease, and hypothyroidism are common culprits in anemia of chronic disease, as are chronic infection and cancer.


Quote:
Epoetin alfa is used to treat anemia


Is it possible that our beloved bree positive traits are Anemia and an under-active Thyroid?

Now if i'm understanding correcting Hyperthyroidism has the same connection, however in the TCC case, it either produces more TCC, or the TCC protien becomexs over active as well and carries too much energy to the cell.
And Epogen is also a known treatment to Hyperthyroidism, except (from what I've read) it doesn't have the same connection to Anemia.

sack36 wrote:I see a problem with this. Working with Mitochondria means you're only working with the mother/daughter link. That leaves Crowley out of the mix. Second, the mitochondria is passed "whole cloth" from mother to daughter so if Bree has it her mom had it. Why tap Bree when they already have her mom?

marlasinger wrote:um, I think sack was saying that they'd tap her biological mom, that is, the one that passed on these traits to her. In order for her to BE an order baby they had to get her from her mother - so I'm assuming at some point the order had the means of grabbing her. An age factor? Okay we'll give you that one. But even then - how does being anemic and a hypothyroidism sufferer (for which she doesn't show symptoms) make Bree special for a ceremony? I'm anemic! Choose me!

marlasinger wrote:um, I think sack was saying that they'd tap her biological mom, that is, the one that passed on these traits to her. In order for her to BE an order baby they had to get her from her mother - so I'm assuming at some point the order had the means of grabbing her. An age factor? Okay we'll give you that one. But even then - how does being anemic and a hypothyroidism sufferer (for which she doesn't show symptoms) make Bree special for a ceremony? I'm anemic! Choose me!

Killthesmiley wrote:very true. but I think like really think this is a beginnng palce.

also remember, her father was trying to stop everything with a controlling shot. so even if she were to have these, the shots would give us an exact opposite to what the epogen.

I know the epogen does have a controling factor with tcc so maybe researching that would be a start