An Proposed Explanation of the Bree Solution
Posted: Thu Jul 12, 2007 2:08 am
So, there has been a lot of awesome work done deciphering the words that have been water-damaged. What’s missing from a lot of this effort, though, is a cohesive theory making sense of the document. Below, I present a theory, developed in collaboration with marlasinger (lovely diagrams courtesy of her, too!), regarding the meaning and significance of the document’s contents.
So, Bree’s blood contains a ribozyme that has a special activity that is unique only to her (Given Fact #1). The gene coding for this ribozyme (in everyone, not just Bree), has a regulatory element that is prone to hypermutation – that is to say, a regulatory portion of the gene mutates frequently (Given Fact #2). We propose that this regulatory element is controlling the correct synthesis of the RNA strand that is complementary to the active coding strand. Put more simply, the coding strand specifies a RNA molecule that is “active” – it is the functional ribozyme that resides in Bree’s blood. Each Hymn of One girl has this gene (Given Fact #3). HOWEVER, each of them also synthesizes the RNA strand that is complementary to this active molecule. This complementary strand binds to the ribozyme, rendering it inactive.
Figure 1.0 – ribozyme; inactive with complementary RNA strand binding to active RNA strand:
Note – complementary colors indicate where strands bind.
But, what makes Bree special is this – the regulatory element has mutated, such that it prevents the correct synthesis of the complementary RNA strand! Thus, the complementary strand is not made, and cannot bind to the active strand – the active strand remains active. Given the interpretation that Given Fact #4 says “this portion (the active strand) still functions, but you cannot block it because the complementary strand won’t copy,” this makes perfect sense. Without the complementary strand to “occlude the activity” of the active strand (Theoretical Solution #3), Bree’s ribozyme remains active.
Figure 1.1 – active strand: normal gene sequence
Figure 1.2 – complementary strand: gene sequence including regulatory gene portion, inhibiting complementary strand synthesis (note: the regulatory element is likely also located on the coding strand, but it is depicted on the complementary strand to reinforce that is where it has its effect).
Note – complementary colors indicate where strands bind.
So, this explains all of the “Given Facts,” but it goes even further – in this context, the treatment makes perfect sense. A blood sample must be taken from Bree, and the active ribozyme isolated. The ribozyme can then be sequenced – once its sequence is known, the sequence of the complementary strand will also be revealed, as in RNA, base A binds with base U on the complementary strand (and vice versa), and base G binds with base C (and vice versa). This complementary strand can be synthesized, and injected into Bree. Bree’s mutated regulatory element renders her unable to make the complementary strand, but once this strand is injected into her, it will bind to her active ribozyme and inactivate it, just as it does in everyone else who naturally synthesizes the complementary strand in their bodies. Given the text that Kellylen, Marla, myself, and others have decoded, this theory explains the proposed treatment as well!
And, this theory may even suggest a reason for the purity bond. As noted in Given Fact #2, the mutation in the regulatory element changes with every generation – it may be possible that if Bree were to have children, the ribozyme would be further destabilized, perhaps becoming uncontrollably active. Because we do not know the function of the ribozyme, we do not know what the consequences of this would be, but given its importance to the Hymn of One, the danger could be vast.
So, in the context of this theory, the pieces of this puzzle – and its solution – begin to assemble together.
So, Bree’s blood contains a ribozyme that has a special activity that is unique only to her (Given Fact #1). The gene coding for this ribozyme (in everyone, not just Bree), has a regulatory element that is prone to hypermutation – that is to say, a regulatory portion of the gene mutates frequently (Given Fact #2). We propose that this regulatory element is controlling the correct synthesis of the RNA strand that is complementary to the active coding strand. Put more simply, the coding strand specifies a RNA molecule that is “active” – it is the functional ribozyme that resides in Bree’s blood. Each Hymn of One girl has this gene (Given Fact #3). HOWEVER, each of them also synthesizes the RNA strand that is complementary to this active molecule. This complementary strand binds to the ribozyme, rendering it inactive.
Figure 1.0 – ribozyme; inactive with complementary RNA strand binding to active RNA strand:
Note – complementary colors indicate where strands bind.
But, what makes Bree special is this – the regulatory element has mutated, such that it prevents the correct synthesis of the complementary RNA strand! Thus, the complementary strand is not made, and cannot bind to the active strand – the active strand remains active. Given the interpretation that Given Fact #4 says “this portion (the active strand) still functions, but you cannot block it because the complementary strand won’t copy,” this makes perfect sense. Without the complementary strand to “occlude the activity” of the active strand (Theoretical Solution #3), Bree’s ribozyme remains active.
Figure 1.1 – active strand: normal gene sequence
Figure 1.2 – complementary strand: gene sequence including regulatory gene portion, inhibiting complementary strand synthesis (note: the regulatory element is likely also located on the coding strand, but it is depicted on the complementary strand to reinforce that is where it has its effect).
Note – complementary colors indicate where strands bind.
So, this explains all of the “Given Facts,” but it goes even further – in this context, the treatment makes perfect sense. A blood sample must be taken from Bree, and the active ribozyme isolated. The ribozyme can then be sequenced – once its sequence is known, the sequence of the complementary strand will also be revealed, as in RNA, base A binds with base U on the complementary strand (and vice versa), and base G binds with base C (and vice versa). This complementary strand can be synthesized, and injected into Bree. Bree’s mutated regulatory element renders her unable to make the complementary strand, but once this strand is injected into her, it will bind to her active ribozyme and inactivate it, just as it does in everyone else who naturally synthesizes the complementary strand in their bodies. Given the text that Kellylen, Marla, myself, and others have decoded, this theory explains the proposed treatment as well!
And, this theory may even suggest a reason for the purity bond. As noted in Given Fact #2, the mutation in the regulatory element changes with every generation – it may be possible that if Bree were to have children, the ribozyme would be further destabilized, perhaps becoming uncontrollably active. Because we do not know the function of the ribozyme, we do not know what the consequences of this would be, but given its importance to the Hymn of One, the danger could be vast.
So, in the context of this theory, the pieces of this puzzle – and its solution – begin to assemble together.
I dont know for sure.. it all sounds kinda crazy to me in my head. but still kinda possible to fit the crazy 'events' that have already happened.